Option (Evidence Strength: Grade C) Major Surgery Major surgery (e.g., substitution cystoplasty, urinary diversion with or without cystectomy) may be undertaken in carefully selected patients with bladder-centric symptoms, or in the rare instance when there is an end-stage small fibrotic bladder, for whom all other therapies have failed to provide adequate symptom control and quality of life improvement
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This can lead to a number of concerns, both internally and externally
doi: 10.1016/j.jcis.2021.09.160 113 GuZLiuTLiuCYangYTangJSongHet al
Lee WH, Morton RA, Epstein JI, Brooks JD, Campbell PA, Bova GS, Hsieh WS, Isaacs WB and Nelson WG
BPC-157 remains unapproved for human use, as large-scale clinical trials confirming its safety and efficacy are still absent, according to the Food and Drug Administration (FDA)
